ACR Appropriateness Criteria® Management of Recurrent Endometrial Cancer.
نویسندگان
چکیده
OBJECTIVES In women with endometrial carcinoma (EC), tumor recurrences tend to occur in the 2- to 3-year period following surgical staging. Management of disease recurrence in EC poses significant challenges. These patients represent a heterogenous group where histologic subtypes, previous adjuvant management, interval since completion of adjuvant therapy, and size and site(s) of disease recurrence all have important implications on salvage therapies and prognosis. No randomized controlled trials have been published to determine optimal management in this group of patients. An expert panel was convened to reach consensus on the most appropriate management options in this group of patients. METHODS The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment. RESULTS Five clinical variants were developed to address common scenarios in the management of women with recurrent EC. Group members reached consensus on the appropriateness of specific evaluation and treatment approaches with numerical ratings. CONCLUSIONS In combining available medical literature and expert opinions, this manuscript may serve as an aid for other practitioners in the appropriate management of women with recurrent EC.
منابع مشابه
American College of Radiology ACR Appropriateness Criteria MANAGEMENT OF RECURRENT ENDOMETRIAL CANCER
Introduction/Background Endometrial cancer (EC) is the most common cancer of the female reproductive organs. More than 54,000 women in the United States are expected to be diagnosed with this disease in 2015 and over 10,000 women will die as a result [1]. The majority of women with EC will be cured after hysterectomy with or without adjuvant therapies. However, approximately 10%–15% of women wi...
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عنوان ژورنال:
- American journal of clinical oncology
دوره 39 5 شماره
صفحات -
تاریخ انتشار 2016